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Alignment of the LIM binding domain of RLIM. The position of the variant c.1067A>G is marked with a yellow box, and is predicted to result in the substitution of the amino acid tyrosine in position 356 by cysteine: p.(Tyr356Cys) or p.(Y356C). Tyr (Y) 356 is located in a highly conserved region of the RNF12 protein, essential for binding to LIM-containing proteins,7 as shown by Ostendorff et al.7
