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. 2015 Apr 15;23(12):1739–1743. doi: 10.1038/ejhg.2015.64

Table 1. Sample size estimates for the simulated non-syndromic hearing impairment study.

Required power Gene MOI CHP a SNV b CHP-M75% c SNV-M75%
0.8 SLC26A4 Recessive 11 40 39 160
0.9 SLC26A4 Recessive 13 45 46 180
0.8 SLC26A4 Compound recessive 11 50 39 200
0.9 SLC26A4 Compound recessive 13 55 46 220
0.8 GJB2 Recessive 12 23 44 92
0.9 GJB2 Recessive 14 28 52 112
0.8 GJB2 Compound recessive 12 25 44 100
0.9 GJB2 Compound recessive 14 34 52 136
0.8 MYO7A Dominant 12 16 31 64
0.9 MYO7A Dominant 14 20 36 80
0.8 MYH9 Dominant 11 13 32 52
0.9 MYH9 Dominant 14 18 41 72

Note: 50% locus heterogeneity is assumed for all scenarios.

a

Number of families required for CHP method.

b

Number of families required for single variant method.

c

‘M75%': number of families required when causal variants in 75% participating families are missing.

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