Table 3.
Change in seizure frequency from baseline and 12-month seizure-free rate
| Seizure frequency | Antiepileptic drugs, n (%) | P | |||||
|---|---|---|---|---|---|---|---|
| CBZ | VPA | TPM | OXC | LTG | LEV | ||
| Reduced by | |||||||
| ≥25% | 156 (84.32) | 189 (82.53) | 43 (84.31) | 77 (87.50) | 78 (76.47) | 79 (77.45) | 0.298 |
| ≥50% | 151 (81.62) | 178 (77.73) | 42 (82.35) | 76 (86.36) | 70 (68.63)* | 78 (76.47) | 0.051 |
| ≥75% | 30 (16.22) | 46 (20.09) | 8 (15.69) | 21 (23.86) | 22 (21.57) | 19 (18.63) | 0.670 |
| 12-month seizure free rate | 101 (54.59) | 109 (47.60) | 30 (58.82) | 45 (51.14) | 33 (32.35)† | 53 (51.96) | 0.006 |
*The responder rate of LTG was lower than OXC significantly, P = 0.001; †The remission rate of LTG was lower than any other drug significantly, P<0.05. CBZ: Carbamazepine; VPA: Valproate; TPM: Topiramate; OXC: Oxcarbazepine; LTG: Lamotrigine; LEV: Levetiracetam.