Table 3.
Hardy–Weinberg equilibrium tests for all Chinese Han participants in this study
| Variants | MS (n = 159) | NMO (n = 163) | Healthy controls (n = 468) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| n (expected numbers) | χ2 | P | n (expected numbers) | χ2 | P | n (expected numbers) | χ2 | P | |
| IL7 | |||||||||
| rs1520333 | 2.547 | 0.110 | 0.071 | 0.790 | 1.892 | 0.169 | |||
| GG | 46 (50.94) | 44 (44.85) | 130 (122.56) | ||||||
| GA | 88 (78.11) | 83 (81.30) | 219 (233.87) | ||||||
| AA | 25 (29.94) | 36 (36.85) | 119 (111.56) | ||||||
| rs1545298 | 0.006 | 0.937 | 0.122 | 0.727 | 0.784 | 0.376 | |||
| CC | 10 (9.81) | 11 (11.88) | 32 (35.83) | ||||||
| CT | 59 (59.37) | 66 (64.25) | 195 (187.33) | ||||||
| TT | 90 (89.81) | 86 (86.88) | 241 (244.83) | ||||||
| rs4739140 | 2.929 | 0.087 | 2.367 | 0.124 | 0.066 | 0.797 | |||
| AA | 0 (2.27) | 6 (3.53) | 6 (6.58) | ||||||
| AG | 38 (33.46) | 36 (40.93) | 99 (97.84) | ||||||
| GG | 121 (123.27) | 121 (118.53) | 363 (363.58) | ||||||
| rs6993386 | 3.089 | 0.079 | 0.077 | 0.782 | 0.143 | 0.705 | |||
| CC | 15 (20.08) | 22 (22.83) | 70 (71.95) | ||||||
| CT | 83 (72.85) | 78 (76.34) | 227 (223.10) | ||||||
| TT | 61 (66.08) | 63 (66.83) | 171 (172.95) | ||||||
| rs7816065 | 0.005 | 0.943 | 0.298 | 0.585 | 0.041 | 0.840 | |||
| CC | 14 (14.19) | 17 (18.56) | 55 (54.02) | ||||||
| CT | 67 (66.62) | 76 (72,88) | 208 (209.96) | ||||||
| TT | 78 (78.19) | 70 (71.56) | 205 (204.02) | ||||||
| rs2887502 | 4.548 | 0.033 | 3.522 | 0.061 | 0.174 | 0.677 | |||
| CC | 0 (3.33) | 8 (4.46) | 11 (9.88) | ||||||
| CT | 46 (39.35) | 39 (45.72) | 114 (116.24) | ||||||
| TT | 113 (116.33) | 116 (112.64) | 343 (341.88) | ||||||
| IL7RA | |||||||||
| rs6897932 | 0.412 | 0.521 | 0.770 | 0.380 | 4.656 | 0.031 | |||
| CC | 111 (112.09) | 111 (109.34) | 329 (335.08) | ||||||
| CT | 45 (42.82) | 45 (48.32) | 134 (121.85) | ||||||
| TT | 3 (4.09) | 7 (5.34) | 5 (11.08) | ||||||
A P < 0.05 was considered statistically significant. MS: Multiple sclerosis; NMO: Neuromyelitis optica; IL7: Interleukin-7; IL7RA: Interleukin-7 receptor alpha.