Table 4.
Allele and genotype distributions of IL7 and IL7R variants among MS, NMO and healthy controls, n (%)
| Variants | Genotype/allele | Controls (n = 468) | MS (n = 159) | NMOT (n = 163) | NMOP (n = 57) | Chi-square or Fisher’s exact values | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| MS versus controls | Total NMO | NMO-IgG positive | ||||||||
| NMOT versus controls | MS versus NMOT | NMOP versus controls | MS versus NMOP | |||||||
| IL7 | ||||||||||
| rs1520333 | GG | 130 (27.78) | 46 (28.93) | 44 (27.00) | 18 (31.58) | χ2 = 6.695, P = 0.035 | χ2 = 1.006, P = 0.605 | χ2 = 2.125, P = 0.346 | χ2 = 0.370, P = 0.831 | χ2 = 2.973, P = 0.226 |
| GA | 219 (46.79) | 88 (55.35) | 83 (50.92) | 25 (43.86) | ||||||
| AA | 119 (25.43) | 25 (15.72) | 36 (22.09) | 14 (24.56) | ||||||
| G | 479 (51.18) | 180 (56.60) | 171 (52.45) | 61 (53.51) | χ2 = 2.805, P = 0.094 | χ2 = 0.158, P = 0.691 | χ2 = 1.118, P = 0.290 | χ2 = 0.222, P = 0.638 | χ2 = 0.222, P = 0.638 | |
| A | 457 (48.82) | 138 (43.40) | 155 (47.55) | 53 (46.49) | ||||||
| IL7RA | ||||||||||
| rs6897932 | CC | 329 (70.30) | 111 (69.81) | 111 (68.10) | 35 (61.40) | χ2 = 0.632*, P = 0.729 | χ2 = 6.745, P = 0.034 | χ2 = 1.551*, P = 0.461 | χ2 = 11.223*, P = 0.004 | χ2 = 4.002*, P = 0.135 |
| CT | 134 (28.63) | 45 (28.30) | 45 (27.61) | 18 (31.58) | ||||||
| TT | 5 (1.07) | 3 (1.89) | 7 (4.29) | 4 (7.02) | ||||||
| C | 792 (84.62) | 267 (83.96) | 267 (81.90) | 88 (77.19) | χ2 = 0.077, P = 0.781 | χ2 = 1.319, P = 0.251 | χ2 = 0.483, P = 0.487 | χ2 = 4.126, P = 0.042 | χ2 = 2.625, P = 0.105 | |
| T | 144 (15.38) | 51 (16.04) | 59 (18.10) | 26 (22.81) | ||||||
*The results of Fisher's exact test. P < 0.05 was considered statistically significant. MS: Multiple sclerosis; NMO: Neuromyelitis optica; NMOT: Total neuromyelitis optica patients; NMOP: Neuromyelitis optica-IgG positive patients; IL7: Interleukin-7; IL7RA: Interleukin-7 receptor alpha.