Table 5.
Allele and genotype distributions of 5 newly studied IL7 variants among MS, NMO and healthy controls, n (%)
| Variants | Genotype/allele | Controls (n = 468) | MS (n = 159) | NMOT (n = 163) | NMOP (n = 57) | Chi-square or Fisher’s exact values | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| MS versus controls | Total NMO | NMO-IgG (+) NMO | ||||||||
| NMOT versus controls | MS versus NMOT | NMOP versus controls | MS versus NMOP | |||||||
| rs1545298 | CC | 32 (6.84) | 10 (6.29) | 11 (7.51) | 2 (3.51) | χ2 = 1.249, P = 0.536 | χ2 = 0.079, P = 0.961 | χ2 = 0.481, P = 0.786 | χ2 = 1.061*, P = 0.588 | χ2 = 1.605*, P = 0.448 |
| CT | 195 (41.67) | 59 (37.11) | 66 (39.31) | 26 (45.61) | ||||||
| TT | 241 (51.50) | 90 (56.60) | 86 (53.18) | 29 (50.88) | ||||||
| C | 259 (27.67) | 79 (24.84) | 88 (26.99) | 30 (26.32) | χ2 = 0.964, P = 0.326 | χ2 = 0.056, P = 0.814 | χ2 = 0.388, P = 0.533 | χ2 = 0.095, P = 0.757 | χ2 = 0.081, P = 0.775 | |
| T | 677 (72.33) | 239 (75.16) | 238 (73.00) | 84 (73.68) | ||||||
| rs4739140 | CC | 6 (1.28) | 0 (0) | 6 (3.68) | 2 (3.51) | χ2 = 2.481*, P = 0.289 | χ2 = 3.882, P = 0.144 | χ2 = 6.005*, P = 0.050 | χ2 = 2.137*, P = 0.344 | χ2 = 5.684*, P = 0.058 |
| CT | 99 (21.15) | 38 (23.90) | 36 (22.09) | 14 (24.56) | ||||||
| TT | 363 (77.56) | 121 (76.10) | 121 (74.23) | 41 (71.93) | ||||||
| C | 111 (11.86) | 38 (11.95) | 48 (14.72) | 18 (15.79) | χ2 = 0.002, P = 0.966 | χ2 = 1.802, P = 0.179 | χ2 = 1.071, P = 0.301 | χ2 = 1.457, P = 0.227 | χ2 = 1.097, P = 0.295 | |
| T | 825 (88.14) | 280 (88.05) | 278 (85.28) | 96 (84.21) | ||||||
| rs6993386 | CC | 70 (14.96) | 15 (9.43) | 22 (13.50) | 5 (8.77) | χ2 = 3.106, P = 0.212 | χ2 = 0.333, P = 0.847 | χ2 = 1.462, P = 0.481 | χ2 = 3.169, P = 0.205 | χ2 = 1.439, P = 0.487 |
| CT | 227 (48.50) | 83 (52.21) | 78 (47.85) | 25 (43.86) | ||||||
| TT | 171 (36.54) | 61 (38.36) | 63 (38.65) | 27 (47.37) | ||||||
| C | 367 (39.21) | 113 (35.53) | 122 (37.42) | 35 (30.70) | χ2 = 1.332, P = 0.249 | χ2 = 0.111, P = 0.739 | χ2 = 0.248, P = 0.619 | χ2 = 3.113, P = 0.078 | χ2 = 0.870, P = 0.351 | |
| T | 569 (60.79) | 205 (64.47) | 204 (62.58) | 79 (69.30) | ||||||
| rs7816065 | CC | 55 (11.75) | 14 (8.81) | 17 (10.43) | 2 (3.51) | χ2 = 1.806, P = 0.405 | χ2 = 0.334, P = 0.846 | χ2 = 1.240, P = 0.538 | χ2 = 4.840*, P = 0.089 | χ2 = 4.064*, P = 0.131 |
| CT | 208 (44.44) | 67 (42.14) | 76 (46.63) | 32 (56.14) | ||||||
| TT | 205 (43.80) | 78 (49.06) | 70 (42.94) | 23 (40.35) | ||||||
| C | 318 (33.97) | 95 (29.87) | 110 (33.74) | 36 (31.58) | χ2 = 1.807, P = 0.179 | χ2 = 0.006, P = 0.939 | χ2 = 1.110, P = 0.292 | χ2 = 0.261, P = 0.609 | χ2 = 0.115, P = 0.734 | |
| T | 618 (66.03) | 223 (70.13) | 216 (66.26) | 78 (68.42) | ||||||
| rs2887502 | CC | 11 (2.35) | 0 (0) | 8 (4.91) | 2 (3.51) | χ2 = 4.790*, P = 0.091 | χ2 = 2.711, P = 0.258 | χ2 = 8.567*, P = 0.014 | χ2 = 0.422*, P = 0.810 | χ2 = 5.685*, P = 0.058 |
| CT | 114 (24.36) | 46 (28.93) | 39 (23.93) | 15 (26.32) | ||||||
| TT | 343 (73.29) | 113 (71.07) | 116 (71.17) | 40 (70.18) | ||||||
| C | 136 (14.53) | 46 (14.47) | 55 (16.87) | 19 (16.67) | χ2 = 0.001, P = 0.977 | χ2 = 1.032, P = 0.310 | χ2 = 0.705, P = 0.401 | χ2 = 0.369, P = 0.544 | χ2 = 0.318, P = 0.573 | |
| T | 800 (85.47) | 272 (95.53) | 271 (83.13) | 95 (83.33) | ||||||
*The results of Fisher's exact test. P < 0.05 was considered statistically significant. MS: Multiple sclerosis; NMO: Neuromyelitis optica; NMOT: Total neuromyelitis optica patients. NMOP: Neuromyelitis optica-IgG positive patients; IL7: Interleukin-7.