. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Metab Brain Dis. 2015 Jul 30;30(6):1505–1514. doi: 10.1007/s11011-015-9704-y

Table 3.

The effects of ferulic acid combined with subthreshold dose of piperine (10 mg/kg) on the concentrations of monoamines and their metabolites in the frontal cortex of mice

Group	Dose (mg/kg)	5-HT	5-HIAA	5-HIAA/5-HT	Noradrenaline	Dopamine	DOPAC
Control		376.9 ± 25.3	189.2 ± 16.5	0.52 ± 0.06	163.0 ± 9.6	49.3 ± 4.4	47.7 ± 4.4
Piperine (10 mg/kg) + FA	313	425.2 ± 16.7	231.0 ± 10.9	0.55 ± 0.03	174.8 ± 5.0	41.2 ± 7.9	48.1 ± 8.8
	10	530.4 ± 27.8^**	239.2 ± 26.6	0.46 ± 0.06	211.5 ± 13.8^*	44.1 ± 4.6	45.3 ± 8.2
	30	555.5 ± 21.9^**	221.0 ± 15.8	0.40 ± 0.03	213.3 ± 11.1^**	49.2 ± 7.1	46.3 ± 8.1
	90	610.4 ± 23.1^***	217.2 ± 15.4	0.36 ± 0.03^*	222.9 ± 10.2^**	49.4 ± 3.8	43.5 ± 7.1
Imipramine	10	549.8 ± 47.8^**	212.3 ± 7.2	0.41 ± 0.04	205.8 ± 11.8^*	58.3 ± 10.7	53.7 ± 10.4

Values are expressed as mean ± S.E.M. with units of ng/g tissue for 10 mice in each group. Data analysis was performed using one-way ANOVA.

P <0.05

^**

P < 0.01 and

^***

P < 0.001, vs. the control group.