Table 5.

The effects of ferulic acid combined with subthreshold dose of piperine (10 mg/kg) on the concentrations of monoamines and their metabolites in the hypothalamus ofmice

Group	Dose (mg/kg)	5-HT	5-HIAA	5-HIAA/5-HT	Noradrenaline	Dopamine	DOPAC
Control		346.5 ± 16.1	242.2 ± 22.3	0.72 ± 0.10	209.2 ± 7.6	446.7 ± 29.5	385.9 ± 70.3
Piperine (10 mg/kg) + FA	3	411.0 ± 27.0	179.0 ± 15.8	0.45 ± 0.06	244.9 ± 27.3	580.6 ± 98.5	425.9 ± 71.3
	10	412.2 ± 47.8	189.2 ± 29.4	0.47 ± 0.06	253.6 ± 26.3	519.9 ± 35.5	409.3 ± 69.6
	30	433.3 ± 22.8	218.1 ± 8.7	0.51 ± 0.03	284.0 ± 17.9	573.0 ± 55.3	386.9 ± 63.8
	90	425.7 ± 42.1	192.6 ± 25.1	0.48 ± 0.08	268.9 ± 24.2	642.5 ± 69.3	367.5 ± 103.0
Imipramine	10	389.1 ± 27.5	240.0 ± 15.3	0.64 ± 0.06	250.5 ± 14.1	537.5 ± 75.2	373.8 ± 65.3

Values are expressed as mean ± S.E.M. with units of ng/g tissue for 10 mice in each group. Data analysis was performed using one-way ANOVA