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The synthetic route of folate/oleic acid-diacylated oligochitosans (left) and schematic preparation of siRNA-loaded folate-cationic liposomes (right).
Abbreviations: siRNA, small interfering RNA; HIF-1α, hypoxia-inducible factor-1α; siRNA-fc-LPs, siRNA-loaded folate-decorated cationic liposomes; NHS, N-hydroxysuccinimide; EDC, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; DMSO, dimethylsulfoxide
