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. 2016 Mar 17;11(3):e0151592. doi: 10.1371/journal.pone.0151592

Fig 4. Effect of mevalonate and squalene on insulin secretion from rosuvastatin-treated INS-1 832/13 cells.

Fig 4

(A) Insulin secretion at basal (2.8 mM) concentrations of glucose from cells treated with 20 μM rosuvastatin (Ros), 50 μM mevalonate (MVA), and 100 μM squalene (Sq) for 48 h as indicated in the figure. (B) Same as in (A) but with stimulatory (16.7 mM) concentrations of glucose instead. (C) Same as in (A) but the cells are stimulated with 50 mM K+ as well. Data are given as mean ± SEM from 3 experiments with 3 technical replicates in each experiment. * p≤ 0.05.