Table 2.
Difference in the overall survival and progression-free survival between high- and low-expression cases of microRNA-150 in the enrolled studies
| References | Method | Cutoff value | Follow-up time (months) | miR-150 expression (number of cases)
|
OS
|
PFS
|
|||
|---|---|---|---|---|---|---|---|---|---|
| High | Low | HR (95% CI) | P-value | HR (95% CI) | P-value | ||||
| Yokobori et al9 | qRT-PCR | Mean expression level | 1–128 | 30 | 78 | 0.77 (0.31, 1.92) | 0.5734 | – | – |
| Dettmer et al14 | qRT-PCR | Fold change =0.2 | 5.1–203.6 | 11 | 15 | 1.57 (0.30, 8.14) | 0.5932 | – | – |
| Ma et al10 | qRT-PCR | The median value | NR | NR | NR | 0.52 (0.31, 0.85) | 0.0132 | – | – |
| Mraz et al6 | qRT-PCR | The median value | NR | NR | NR | 0.36 (0.17, 0.77) | 0.0076 | – | – |
| Ciruelos et al8 | qRT-PCR | NR | NR | NR | NR | 4.51 (2.36, 8.61) | 0.0000 | 3.75 (2.27, 6.19) | 0.0000 |
| Lee et al11 | qRT-PCR | The median value | NR | 111 | 110 | 1.69 (1.25, 2.27) | 0.0007 | – | – |
| Lee et al11 | qRT-PCR | The median value | NR | 93 | 96 | 1.74 (1.26, 2.41) | 0.0008 | – | – |
| Stamatopoulos et al19 | qRT-PCR | The median value | 7–380 | 180 | 93 | 0.53 (0.31, 0.93) | 0.0203 | – | – |
| Stamatopoulos et al19 | qRT-PCR | The median value | 7–380 | 133 | 119 | 2.06 (1.02, 4.15) | 0.0439 | – | – |
| Bi et al7 | qRT-PCR | NR | 4.4–104.2 | 20 | 20 | 3.05 (0.57, 16.39) | 0.1926 | 1.6 (0.52, 4.97) | 0.4124 |
| Bi et al7 | qRT-PCR | NR | 9–81 | 21 | 21 | 2.12 (0.54, 8.22) | 0.2816 | 2.02 (0.56, 7.30) | 0.2828 |
| Fleming et al20 | qRT-PCR | Risk score cutoff: 0.2 | 17.5–128.9 | 106 | 95 | 2.21 (0.68, 7.19) | 0.1873 | – | – |
| Fleming et al20 | qRT-PCR | Risk score cutoff: 0.2 | 0.8–95.0 | 41 | 41 | 2.34 (0.43, 12.78) | 0.3253 | – | – |
Note: HR, high vs low.
Abbreviations: CI, confidence interval; HR, hazard ratio; miR-150, microRNA-150; NR, no reference; OS, overall survival; PFS, progression-free survival; qRT-PCR, quantitative reverse transcription-polymerase chain reaction.