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. 2016 Mar 17;11(3):e0151845. doi: 10.1371/journal.pone.0151845

Fig 2. Metformin and telmisartan enhance AMPK and PARP1 phosphorylation in HUVECs.

Fig 2

Western blot analysis of AMPK Thr-172 and PARP1 Ser-177 phosphorylation in HUVECs treated with concentrations of metformin (A), glipizide (B), telmisartan (C), and metoprolol (D) for 4 hr or (E-H) metformin (5 mM), glipizide (500 nM), telmisartan (5 μM), and metoprolol (500 μM) for the indicated times. Data are mean±SD ratio of phospho-PARP1 to total PARP1 and phospho-AMPK to total AMPK from 3 independent experiments. *p<0.05 compared to controls.