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. 2016 Mar 17;11(3):e0151845. doi: 10.1371/journal.pone.0151845

Fig 3. Metformin and telmisartan induce AMPK and PARP1 phosphorylation in mouse aortas.

Fig 3

Twelve week-old male C57BL6 mice were administered (A) metformin (200 mg/kg body weight), (B) glipizide (1.3 mg/kg body weight), (C) telmisartan (10 mg/kg body weight), or (D) metoprolol (30 mg/kg body weight) for the indicated times. Control mice received 0.5 ml saline. Western blot analysis of AMPK and PARP1 phosphorylation in aortic extracts from 2 mice pooled. Data are mean ± SD ratio of phospho-PARP1 to total PARP1 and phospho-AMPK to total AMPK (n = 8 mice per group). *p<0.05 compared to controls.