Skip to main content
. 2016 Mar 17;11(3):e0151584. doi: 10.1371/journal.pone.0151584

Fig 15. Gene expression changes as a result of NAC-treatment in sorted HSC and MkP populations.

Fig 15

a) Gene expression changes as a result of loss of Meis1 in the sorted HSC population treated with NAC or PBS. In PBS treated mice, there is a significant difference between MxCre/Meis1-/- mice and MxCre/Meis1-/+ mice in the expression of Meis1 (115-fold), Hlf (21-fold), Msi2 (4.3-fold) and Hbb-b1(8-fold gain). While differences persist with NAC treatment the magnitude is blunted compared to PBS treated mice: Meis1 (4-fold), Hlf (4-fold), Msi2 (2-fold) and Hbb-b1(12-fold gain). b) Very few significant gene expression changes were found between MxCre/Meis1-/- and MxCre/Meis1-/+ treated MkP cells. In PBS treated mice, there was a 47-fold drop in Meis1 expression and in NAC treated mice, a 8-fold loss of Hlf and 140-fold gain in Hbb-b1 expression.