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. 2016 Mar 17;11(3):e0150850. doi: 10.1371/journal.pone.0150850

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© 2016 Khalid et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — A. Principal component analysis of IDUA^-/- canine arteries compared to control canine arteries clearly shows the formation of two sample clusters separating IDUA^-/- and control expression. B. WGCNA dendrogram on the microarray samples showing different modules related to the Pearson correlation of the IDUA^-/- and control samples. C. Heatmaps of the two major modules (turquoise and blue) formed by WGCNA showing genes upregulated (top panel) or downregulated (bottom panel) by IDUA deficiency. D. Genes significantly upregulated in IDUA^-/- canine arteries include those related to immunity / inflammation (KEGG pathways: antigen processing and presentation, graft-versus-host disease), proteasomal function, and lysosomal function. E. Genes significantly downregulated in IDUA^-/- canine arteries are primarily related to cellular adhesion and the cytoskeleton (placed into the dilated cardiomyopathy, focal adhesion, arrhythmogenic right ventricular cardiomyopathy KEGG pathways).