Table 1. Upregulated Genes in IDUA-/- Canine Arteries.
The 50 upregulated genes with significant (p-value ≤ 0.05) and greater than 2-fold level of upregulation in IDUA-/- canine arteries, compared to controls. Note that some genes are represented more than once due to existence of multiple mRNA probes per gene. For the full list of significantly upregulated genes, please refer to S1 Table.
| Fold Change | Gene Symbol | Systematic Name | Description |
|---|---|---|---|
| 27.126 | GPNMB | XM_858105 | PREDICTED: Canis familiaris similar to glycoprotein (transmembrane) nmb isoform b precursor, transcript variant 3 (LOC482355), mRNA [XM_858105] |
| 20.245 | GPNMB | XM_858105 | PREDICTED: Canis familiaris similar to glycoprotein (transmembrane) nmb isoform b precursor, transcript variant 3 (LOC482355), mRNA [XM_858105] |
| 12.432 | ENSCAFT00000039657 | ENSCAFT00000039657 | Osteopontin (Fragment) |
| 11.926 | CSTB | XM_535601 | PREDICTED: Canis familiaris similar to Cystatin B |
| 11.566 | ENSCAFT00000039661 | ENSCAFT00000039661 | Osteopontin (Fragment) |
| 10.506 | DLA-DRA1 | ENSCAFT00000001254 | MHC class II DR alpha chain |
| 10.220 | CLU | NM_001003370 | Canis lupus familiaris clusterin (CLU) |
| 9.595 | CLU | NM_001003370 | Canis lupus familiaris clusterin (CLU) |
| 9.464 | CTSK | ENSCAFT00000035613 | Cathepsin K precursor |
| 8.985 | TC71707 | TC71707 | Q49RE5_CANFA (Q49RE5) Cytochrome b, partial (35%) |
| 7.766 | CSTB | XM_535601 | PREDICTED: Canis familiaris similar to Cystatin B |
| 7.587 | LOC479746 | XM_536874 | PREDICTED: Canis familiaris similar to Ferritin light chain 2 |
| 7.022 | TC57368 | TC57368 | HUMLPLSTN2 L-plastin {Homo sapiens} |
| 6.975 | GPNMB | XM_858105 | PREDICTED: Canis familiaris similar to glycoprotein (transmembrane) nmb isoform b precursor, transcript variant 3 (LOC482355), mRNA [XM_858105] |
| 6.968 | CLU | NM_001003370 | Canis lupus familiaris clusterin (CLU) |
| 6.947 | CD86 | NM_001003146 | Canis lupus familiaris CD86 molecule (CD86) |
| 6.769 | DR104862 | DR104862 | Canine cardiovascular system biased cDNA |
| 6.738 | FTL | NM_001024636 | Canis lupus familiaris ferritin, light polypeptide |
| 6.718 | CTSS | NM_001002938 | Canis lupus familiaris cathepsin S (CTSS) |
| 6.704 | CLU | NM_001003370 | Canis lupus familiaris clusterin (CLU) |
| 6.677 | APOE | XM_847504 | PREDICTED: Canis familiaris apolipoprotein E, transcript variant 2 (APOE) |
| 6.666 | CTSK | NM_001033996 | Canis lupus familiaris cathepsin K (CTSK) |
| 6.655 | CTSK | NM_001033996 | Canis lupus familiaris cathepsin K (CTSK) |
| 6.605 | LGMN | XM_537355 | PREDICTED: Canis familiaris similar to Legumain precursor |
| 6.453 | CTSK | NM_001033996 | Canis lupus familiaris cathepsin K (CTSK) |
| 6.423 | DLA-DRB1 | NM_001014768 | Canis lupus familiaris MHC class II DLA DRB1 beta chain (DLA-DRB1) |
| 6.193 | FTL | NM_001024636 | Canis lupus familiaris ferritin, light polypeptide (FTL) |
| 6.178 | CTSK | NM_001033996 | Canis lupus familiaris cathepsin K (CTSK) |
| 6.055 | TYRP1 | XM_859450 | PREDICTED: Canis familiaris tyrosinase-related protein 1 (TYRP1) |
| 6.026 | CTSK | NM_001033996 | Canis lupus familiaris cathepsin K (CTSK) |
| 6.013 | BPI | XM_534417 | PREDICTED: Canis familiaris similar to Bactericidal permeability-increasing protein precursor (BPI) |
| 6.006 | CTSB | XM_543203 | PREDICTED: Canis familiaris similar to cathepsin B preproprotein |
| 5.833 | TC50899 | TC50899 | Q9N2I5_FELCA (Q9N2I5) CD16 |
| 5.828 | TC62836 | TC62836 | FCU92795 fusin {Felis catus} |
| 5.727 | LGMN | XM_537355 | PREDICTED: Canis familiaris similar to Legumain precursor |
| 5.680 | DLA-DQB1 | NM_001014381 | Canis lupus familiaris MHC class II, DQ beta 1 (DLA-DQB1) |
| 5.660 | CSGALNACT1 | XM_539946 | PREDICTED: Canis familiaris similar to chondroitin beta1,4 N-acetylgalactosaminyltransferase |
| 5.651 | MT2A | NM_001003149 | Canis lupus familiaris metallothionein 2A (MT2A) |
| 5.493 | TC51307 | TC51307 | Unknown |
| 5.331 | TGM2 | XM_542991 | PREDICTED: Canis familiaris similar to Protein-glutamine gamma-glutamyltransferase |
| 5.306 | SMOC2 | XM_858080 | PREDICTED: Canis familiaris similar to secreted modular calcium-binding protein 2 |
| 5.190 | ASAH1 | XM_540012 | PREDICTED: Canis familiaris similar to N-acylsphingosine amidohydrolase (acid ceramidase) |
| 5.152 | APOE | ENSCAFT00000007432 | Apolipoprotein E (Apo-E) |
| 5.104 | TC54889 | TC54889 | Unknown |
| 5.069 | DLA-DRA1 | NM_001011723 | Canis lupus familiaris MHC class II DR alpha chain (DLA-DRA1) |
| 4.984 | RRAGD | XM_532231 | PREDICTED: Canis familiaris similar to Ras-related GTP binding D |
| 4.921 | E02824 | E02824 | Canis familiaris cDNA clone LIB30321_005_G04 |
| 4.912 | RRAGD | XM_532231 | PREDICTED: Canis familiaris similar to Ras-related GTP binding D |
| 4.902 | TYROBP | XM_533687 | PREDICTED: Canis familiaris similar to TYRO protein tyrosine kinase binding protein isoform 2 precursor |
| 4.882 | FTH1 | ENSCAFT00000025200 | Ferritin heavy chain (EC 1.16.3.1) (Ferritin H subunit) |