Table 4. Down-regulated Canine Arterial IDUA-/- Genes Sorted by Category.
Down-regulated arterial genes in IDUA-/- dogs fall into categories associated with cytoskeletal proteins, cellular adhesion, and ion channels (termed arrhythmogenic right ventricular cardiomyopathy, focal adhesion, and dilated cardiomyopathy).
| Ontology Category | ||
|---|---|---|
| "ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY" | ||
| Systematic Name | Gene Name | Entrez Gene ID |
| ACTB | actin, beta | 610787 |
| ACTN1 | actinin, alpha 1 | 480369 |
| ACTN2 | actinin, alpha 2 | 479191 |
| ACTN4 | actinin, alpha 4 | 484526 |
| LOC442937 | beta-actin | 442937 |
| CACNA1S | calcium channel, voltage-dependent, L type, alpha 1S subunit | 490244 |
| CACNB1 | calcium channel, voltage-dependent, beta 1 subunit | 491030 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 487113 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 609361 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 2 | 483088 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 489008 |
| DES | desmin | 497091 |
| DSC2 | desmocollin 2 | 403860 |
| DMD | dystrophin (muscular dystrophy, Duchenne and Becker types) | 606758 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 403418 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 486493 |
| ITGA6 | integrin, alpha 6 | 478800 |
| ITGA8 | integrin, alpha 8 | 487119 |
| ITGA9 | integrin, alpha 9 | 477021 |
| ITGB4 | integrin, beta 4 | 483318 |
| ITGB8 | integrin, beta 8 | 475253 |
| RYR2 | ryanodine receptor 2 (cardiac) | 403615 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 486043 |
| LOC492249 | similar to Emerin | 492249 |
| "DILATED CARDIOMYOPATHY" | ||
| Systematic Name | Gene Name | Entrez Gene ID |
| GNAS | GNAS complex locus | 403943 |
| ACTB | actin, beta | 610787 |
| ADCY2 | adenylate cyclase 2 (brain) | 478624 |
| ADCY5 | adenylate cyclase 5 | 403859 |
| ADCY9 | adenylate cyclase 9 | 490031 |
| LOC442937 | beta-actin | 442937 |
| CACNA1S | calcium channel, voltage-dependent, L type, alpha 1S subunit | 490244 |
| CACNB1 | calcium channel, voltage-dependent, beta 1 subunit | 491030 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 487113 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 609361 |
| DES | desmin | 497091 |
| DMD | dystrophin (muscular dystrophy, Duchenne and Becker types) | 606758 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 486493 |
| ITGA6 | integrin, alpha 6 | 478800 |
| ITGA8 | integrin, alpha 8 | 487119 |
| ITGA9 | integrin, alpha 9 | 477021 |
| ITGB4 | integrin, beta 4 | 483318 |
| ITGB8 | integrin, beta 8 | 475253 |
| PLN | phospholamban | 414755 |
| RYR2 | ryanodine receptor 2 (cardiac) | 403615 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 486043 |
| LOC492249 | similar to Emerin | 492249 |
| TTN | titin | 478819 |
| TPM3 | tropomyosin 3; tropomyosin 1 (alpha); similar to tropomyosin 1 alpha chain isoform 4 | 478332; 480137; 484695; 491970 |
| TNF | tumor necrosis factor (TNF superfamily, member 2) | 403922 |
| "FOCAL ADHESION" | ||
| Systematic Name | Gene Name | Entrez Gene ID |
| RAP1A | RAP1A, member of RAS oncogene family | 483225 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 491286 |
| ARHGAP5 | Rho GTPase activating protein 5 | 490642 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 480181 |
| ACTB | actin, beta | 610787 |
| ACTN1 | actinin, alpha 1 | 480369 |
| ACTN2 | actinin, alpha 2 | 479191 |
| ACTN4 | actinin, alpha 4 | 484526 |
| LOC442937 | beta-actin | 442937 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 403980 |
| CAV2 | caveolin 2 | 403611; 475294 |
| COL1A1 | collagen, type I, alpha 1 | 403651 |
| COL1A2 | collagen, type I, alpha 2 | 403824 |
| COL2A1 | collagen, type II, alpha 1 | 403826 |
| COL4A1 | collagen, type IV, alpha 1 | 403496 |
| COL5A1 | collagen, type V, alpha 1 | 480684 |
| COL6A3 | collagen, type VI, alpha 3 | 403582 |
| FLNC | filamin C, gamma (actin binding protein 280) | 482266 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 486493 |
| ITGA6 | integrin, alpha 6 | 478800 |
| ITGA8 | integrin, alpha 8 | 487119 |
| ITGA9 | integrin, alpha 9 | 477021 |
| ITGB4 | integrin, beta 4 | 483318 |
| ITGB8 | integrin, beta 8 | 475253 |
| LAMA3 | laminin, alpha 3 | 480173 |
| LAMB2 | laminin, beta 2 (laminin S) | 476626 |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 403438 |
| MAPK8 | mitogen-activated protein kinase 8 | 477746 |
| MYLK | myosin light chain kinase | 488012 |
| MYLK2 | myosin light chain kinase 2 | 477187 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | 484513 |
| PIK3CA | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 488084 |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 609956 |
| PGF | placental growth factor | 611916 |
| PDGFD | platelet derived growth factor D | 479460 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 442985 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isoform | 403558 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isoform | 403557 |
| PPP1R12A | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 475411 |
| RHOA | ras homolog gene family, member A | 403954 |
| LOC479252 | similar to Vinculin (Metavinculin) | 479252 |
| LOC479790 | similar to mitogen activated protein kinase 3 | 479790 |
| TLN1 | talin 1 | 474759 |
| TNC | tenascin C | 481689 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 449021 |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 608125 |