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. 2016 Mar 17;11(3):e0151896. doi: 10.1371/journal.pone.0151896

Table 6. Recommendations regarding the diagnostic tests.

Recommendation Average value* Inter-hospital range P value
Q10. GOLD 2013. Decline in lung function is best tracked by spirometry performed at least once a year 497 (80.0) 30–100 < 0.001
Q11. GOLD 2013. Spirometry should be performed after the administration of an adequate dose of a short-acting inhaled bronchodilator to minimize variability 352 (56.7) 0–94.9 < 0.001
Q12. GOLD 2013. A chest X-ray is valuable in excluding alternative diagnoses and establishing the presence of significant comorbidities 426 (68.6) 19.2–100 < 0.001
Q13. GOLD 2013. Computed tomography (CT) of the chest is not routinely recommended
 • Cases with CT scan performed 96 (15.5) 2.5–37.5 < 0.001
Q14. GesEPOC. Indications for a chest CT scan are (n = 96):
 • Diagnosis of bronchiectasis 14 (14.6) 0–33.3 0.021
 • Exclusion of other associated lung diseases 57 (59.4) 0–100 0.001
 • Diagnosis and evaluation of emphysema 16 (16.7) 0–100 0.002
 • Indication not available 9 (9.4) 0–46.7 < 0.001
Q15. SEPAR 2009. Serum α1-antitrypsin concentrations should be determined for all COPD patients at least once
 • Serum α1-antitrypsin concentrations evaluated at some time point 190 (30.6) 2.5–62.3 < 0.001
Q16. GOLD 2013. Monitoring of physical activity may be more prognostically relevant prognosis than evaluating exercise capacity 403 (64.9) 24.7–100 < 0.001
Q17. SEPAR 2009. Patients with severe or very severe COPD should undergo the following test at least one time: maximal exercise test (n = 174) 1 (0.6) 0–50 < 0.001

* Average value expressed as the mean (standard deviation) or absolute (relative) frequency depending on the nature of the variable.

Calculated for the variability between centers using ANOVA or Chi-square, depending on the nature of the variable. Percentages refer to the whole population (n = 621) unless otherwise indicated. GOLD 2013: Global Initiative for Obstructive Lung Disease 2013 [19]; SEPAR 2009: SEPAR Health-Care Quality Standards 2009 [21]; GesEPOC 2012: Spanish National Guideline for COPD [22].