Table 1. Relative frequency of the various type of amino acid substitutions within the TM regions associated with polymorphisms.

%	charged	non-polar	Polar
Charged	1,67±0,1	2,06±0,09	1,29±0,07
non-polar	4,22±0,13	53,83±0,41	18,35±0,35
Polar	2,65±0,1	13,09±0,23	2,84±0,11