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. 2016 Mar 17;11(3):e0151760. doi: 10.1371/journal.pone.0151760

Table 2. Relative frequency of the various type of amino acid substitutions within the TM regions associated with diseases.

% Charged non-polar polar
charged 3,68±0,2 3,86±0,15 3,94±0,12
non-polar 22,61±0,42 33,09±0,24 12,1±0,3
Polar 5,85±0,18 11,35±0,22 3,5±0,11