Fig 3. Relative cGMP_T levels after single, paired, and triple kinetic perturbations of the oxidatively impaired NO˙-cGMP pathway.

The relative level of cGMP_T as a function of all possible single (13 brown bars), paired (78 gray bars), and triple (286 green bars) perturbations is shown. Values of the rate constants were reduced to 10% of their original values (S1 Table). Each bar shows the relative integrated cGMP levels over the period of simulation, or $cGM{P}_{\text{T}}={\displaystyle {\int }_0^{\text{T}}[cGMP](t)dt}$. Note that some of the optimal perturbations are highlighted in this figure.