Table 2. Comparison of Sirt1/2 inhibition of isolated and synthesized javamide-II.
Sirt1/2 inhibition activity was measured as described in “Materials and Methods”. Data are presented as mean ± SD (n = 6). The data in the parentheses are Sirt1 inhibition.
| Concentrations (μM) | Residual Sirt1/2 activity | |
|---|---|---|
| Isolated | Synthesized | |
| 0 | 100±11.9 (100±9.7)% | 100±10.1 (100±9.9)% |
| 1 | 81±9.9 (91±9.5)% | 80±10.9 (90±9.7)% |
| 5 | 61±9.2 (82±9.1)% | 60±9.9 (81±8.5)% |
| 10 | 41±8.8 (76±8.5)% | 41±9.0 (76±9.1)% |
| 20 | 31±8.2 (65±9.5)% | 31±8.7 (64±9.5)% |