Table 2. Levels of serum myoglobin, biochemical indexes and HO-1 enzymatic activity. (mean±SD, n = 6).
| Group | Time | Myoglobin (ng/ml) | BUN (mg/dl) | Cr (mg/dl) | CK (U/L) | HO-1 activity (pmol/mg/h) |
|---|---|---|---|---|---|---|
| Control | 1 h | 2.3±0.8 | 16.3±2.8 | 0.29±0.06 | 463±66 | 163±24 |
| Control | 6 h | 2.2±0.9 | 18.4±4.6 | 0.25±0.04 | 514±84 | 188±21 |
| Control | 24 h | 2.7±0.9 | 16.5±3.3 | 0.28±0.07 | 425±63 | 171±17 |
| AKI | 1 h | 244.5±41.4* | 36.6±6.1* | 0.69±0.13* | 15567±1783* | 217±30* |
| AKI | 6 h | 334.3±18.4* | 59.8±10.8* | 0.81±0.14* | 19885±2583* | 253±27* |
| AKI | 24 h | 5.6±3.0 | 88.8±13.5* | 2.80±0.38* | 3308±381* | 318±35* |
| PHC | 1 h | 239.6±44.7* | 27.9±3.2*+ | 0.44±0.07†# | 16455±1968* | 274±27*# |
| PHC | 6 h | 215.4±56.9*# | 38.5±6.8*# | 0.60±0.12*# | 18772±2368* | 305±29*# |
| PHC | 24 h | 3.6±3.0 | 73.5±13.4*+ | 2.21±0.29*+ | 3140±402* | 498±55*# |
| ZnPP | 1 h | 311.4±41.2*#^ | 42.6±9.7*^ | 0.77±0.12*^ | 14539±1984* | 152±20#^ |
| ZnPP | 6 h | 362.7±14.6*^ | 65.0±9.6*^ | 0.96±0.14*^ | 19645±2402* | 210±30#^ |
| ZnPP | 24 h | 34.1±8.8*#^ | 113.0±16.1*#^ | 4.07±0.62*#^ | 3569±355*˅ | 269±28*+^ |
| PHC+ZnPP | 1 h | 274.7±17.3* | 37.9±6.1*^ | 0.72±0.15*^ | 16561±2086* | 167±26#^ |
| PHC+ZnPP | 6 h | 352.6±22.4*^ | 48.6±5.6*+˅ | 0.93±0.18*^ | 19076±2096* | 216±27+^ |
| PHC+ZnPP | 24 h | 21.5±6.0*#^ | 89.6±12.6*˅ | 3.28±0.43*^ | 3106±374* | 294±27*^ |
Abbreviations: BUN, urea nitrogen; Cr, creatinine; CK, creatine kinase; HO-1, heme oxygenase 1.
Compared with simultaneous group
* P<0.01 or
† P<0.05 vs. Control
# P<0.01 or
+ P<0.05 vs. AKI
^ P<0.01 or
˅ P<0.05 vs. PHC.