Table 3.
Linear spline regression coefficients above and below a single knot per SD of baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) on hazard ratios of incident diabetes during 9.5 years of follow-up of 4872 individuals without diabetes at baseline in the Multi-Ethnic Study of Atherosclerosis (MESA).
| NT-proBNP cutoff (pg/mL) | Coefficient (SE) | NT-proBNP SD < knot (pg/mL) | P | Coefficient (SE) | NT-proBNP SD ≥ knot (pg/mL) | P | P for interaction |
|---|---|---|---|---|---|---|---|
| 35 | −0.07 (0.08) | 17.2 | 0.4 | −0.04 (0.06) | 138.8 | 0.5 | 0.5 |
| 45 | −0.11 (0.07) | 21.8 | 0.1 | 0.02 (0.06) | 153.8 | 0.8 | 0.1 |
|
| |||||||
| 55 | −0.15 (0.07) | 25.8 | 0.02 | 0 (0.07) | 168.6 | 1.0 | 0.03 |
|
| |||||||
| 80 | −0.21 (0.06) | 34.8 | 0.0006 | 0.06 (0.08) | 209.4 | 0.4 | 0.0007 |
| 100 | −0.24 (0.06) | 40.5 | <0.0001 | 0.12 (0.08) | 240.2 | 0.2 | <0.0001 |
| 120 | −0.23 (0.06) | 45.4 | <0.0001 | 0.14 (0.09) | 271.7 | 0.09 | <0.0001 |
| 140 | −0.25 (0.06) | 49.7 | <0.0001 | 0.18 (0.10) | 302.8 | 0.05 | <0.0001 |
|
| |||||||
| 150 | −0.20 (0.05) | 49.7 | <0.0001 | 0.22 (0.10) | 319.7 | 0.04 | <0.0001 |
|
| |||||||
| 200 | −0.18 (0.05) | 60.0 | 0.0002 | 0.28 (0.13) | 400.0 | 0.02 | <0.0001 |
| 300 | −0.14 (0.05) | 63.9 | 0.002 | 0.48 (0.2) | 589.1 | 0.02 | 0.005 |
Values were regressed on baseline NT-proBNP multiplied by SD of baseline NT-proBNP at each cutoff value; coefficients were adjusted for age, race, gender, antihypertensive medication, statin use, educational attainment, plasma interleukin-6 and total intentional exercise (MET-min/week); upper grey row: lowest knot below which the slope of association between incident diabetes and baseline NT-proBNP is inversed but, above the knot, plateaus; lower grey row: knot below which there is an inverse association between incident diabetes and baseline NT-proBNP but is, above the knot, positive.