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. 2016 Feb 25;1(2):e84897. doi: 10.1172/jci.insight.84897

Figure 3. Hyperacetylated mitochondrial proteins in failing human heart are involved in multiple energy transduction pathways.

Figure 3

Lysine-acetylated proteins (indicated by circles, protein symbols are noted) identified by mass spectrometry in dilated cardiomyopathy (DCM) patients and nonfailing (NF) control samples (n = 5/group) in each of the 3 main mitochondrial fuel oxidation/ATP synthesis pathways (β-oxidation, tricarboxylic acid [TCA] cycle, and electron transport complex [ETC]) are shown. All acetylated residues with at least ± 1.5 fold change for mean DCM/NF values are shown. Mean DCM acetylation levels that were significantly different compared to NF control values based on Student’s t test are also indicated (*P < 0.05). Specific lysine acetylation sites are noted in parentheses. Acetylation status is indicated by color coding: proteins with increased acetylation (DCM/NF) are in red; proteins with decreased acetylation are in blue; and proteins with no significant change are in gray. All acetylation levels were normalized to corresponding protein abundance. SDHA, succinate dehydrogenase A.