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Enantioselective Synthesis of Spiroindolone Scaffolds
 | ||||||
|---|---|---|---|---|---|---|
| entry | R | isatin | product | catalyst | yield (%)a | %eeb |
| 1 | H | 3a | 16a | Sc(OTf)3 | 89 | -- |
| 2 | 5-F | 3b | 16b | 20 | 86 | 84 |
| 3 | 7-F | 3f | 16f | Thiourea | 92c | -- |
Isolated yield.
Determined using HPLC analysis with chiral stationary phase.
Reaction was performed in DCM solvent.
