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. Author manuscript; available in PMC: 2016 Mar 17.
Published in final edited form as: ACS Comb Sci. 2012 Apr 2;14(4):285–293. doi: 10.1021/co300003c

Table 5.

Synthesis of Triazole-functionalized Oxindoles and Isatins from Aryl-iodides

graphic file with name nihms368205t5.jpg
entry R1 isatin/oxindole Ar-N3a product yield (%)b
1c 4-Cl 3c 12g 8ca 23
2c 5-OMe 3e 12h 8eh 35
3d 5-F 14b 12i 5bi 28
4d 4-Cl 14c 12i 5ci 40
5d 4-Cl 15c 12i 6ci 19
a

Azide generated in situ from the corresponding aryl-iodide.

b

Isolated yield.

c

Reactions performed using CuI (10 mol %), and DMEDA (15 mol %) according to Scheme 3, eq 3.

d

Reaction performed with 1 equiv of CuSO4•5H2O, and 1.1 equiv. of sodium ascorbate.