Table 1.
Associations Between Dementia (Or Definite Cognitive Impairment) At last Examination and the Presence of Neuropathologic Lesions at Autopsy Among 443 Decedents
| Group | NFT/NP | Microvascular Infarcts | Atrophy | Total no. of Men in Lesion Group | No. of Men (%) with Dementia or Definite Impairment | Mean CASI | Odds Ratio (95%CI) |
|---|---|---|---|---|---|---|---|
| 0 | 0 | 0 | 0 | 156 | 32 (20%) | 76 | 1.0 (ref) |
| 1 | + | 0 | 0 | 32 | 14 (44%) | 64 | 2.5 (1.1- 5.9) |
| 2 | 0 | + | 0 | 66 | 23 (38%) | 67 | 2.1 (1.1- 4.1) |
| 3 | 0 | 0 | + | 55 | 34 (62%) | 55 | 5.7 (2.8- 11.3) |
| 4 | + | + | 0 | 19 | 11 (58%) | 50 | 5.2 (1.9- 14.5) |
| 5 | + | 0 | + | 37 | 29 (78%) | 32 | 12.1 (4.9- 30.1) |
| 6 | 0 | + | + | 53 | 36 (68%) | 48 | 8.9 (4.3- 18.2) |
| 7 | + | + | + | 25 | 21 (84%) | 33 | 20.6 (6.4- 66.5) |
| All groups | 443 | 200 (45%) |