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. Author manuscript; available in PMC: 2017 Mar 16.
Published in final edited form as: Neuron. 2016 Feb 25;89(6):1208–1222. doi: 10.1016/j.neuron.2016.01.042

Figure 4. Diminished Myelin Sheath Thickness in the Ts65Dn Corpus Callosum.

Figure 4

(A and B) Representative electron micrographs of axon cross sections in the P60 euploid control (A) and Ts65Dn (B) corpus callosum. Scale bar = 1 μm.

(C) Graph of the numbers of myelinated axons in euploid versus Ts65Dn revealing a trend towards a decrease in the number of myelinated axons in Ts65Dn mice.

(D) Histogram indicating a decrease in the proportion of small diameter axons and an increase in the proportion of large diameter axons (>1 μm) in Ts65Dn mice. *, p≤0.05; #, p=0.058 (paired t-test).

(E) Plot of g-ratios (y-axis) and the corresponding diameter for all axons assessed. Black dots = euploid control; red dots = Ts65Dn.

(F) Bar graph showing there is a significant increase in the mean g-ratio in Ts65Dn mice indicating thinner myelin sheaths around Ts65Dn axons. *, p=0.011 (paired t-test).

(G) Histogram indicating that the g-ratios of small diameter, but not large diameter axons, are higher in Ts65Dn mice. #, p≤0.08 (paired t-test).