Table 2.
Predictors of incident RLS using logistic regression analysis in the entire cohort (n=3,519,773)
| Odds Ratio (OR) | 95% confidence interval of OR |
|
|---|---|---|
| Age (+10 year) | 1.01 | 0.98 – 1.04 |
| Gender: female vs male (ref.) | 1.37 | 1.19 – 1.56 |
| Race: | ||
| White (ref.) | 1.00 | 1.00-1.00 |
| African-American | 0.28 | 0.24 – 0.32 |
| Hispanic | 0.29 | 0.20 – 0.42 |
| Other Race | 0.77 | 0.61 – 0.97 |
| Income (+1 log) | 0.91 | 0.88 – 0.94 |
| Marital status: Unmarried vs married (ref.) | 1.10 | 1.03 – 1.18 |
| Baseline eGFR (+10 ml/min./1.73m2) | 1.03 | 1.00 – 1.05 |
| Presence of diabetes vs absence of diabetes (ref.) | 1.22 | 1.13 – 1.32 |
| Presence of hypertension vs absence of hypertension (ref.) | 1.04 | 0.96 – 1.12 |
| Presence of Cardiovascular Disease vs absence of Cardiovascular Disease (ref.) | 1.13 | 1.03 – 1.24 |
| Presence of Congestive Heart Failure vs absence of Congestive Heart Failure (ref.) | 1.14 | 0.99 – 1.30 |
| Presence of Cerebrovascular Disease* vs absence of Cerebrovascular Disease* (ref.) | 1.09 | 0.96 – 1.23 |
| Presence of Peripheral Arterial Disease vs absence of Peripheral Arterial Disease (ref.) | 1.43 | 1.27 – 1.60 |
| Presence of Chronic Lung Disease vs absence of Chronic Lung Disease (ref.) | 1.52 | 1.42 – 1.64 |
| Presence of Dementia vs absence of dementia (ref.) | 0.71 | 0.47 – 1.07 |
| Presence of Rheumatologic Disease vs absence of Rheumatologic Disease (ref.) | 1.14 | 0.90 – 1.45 |
| Presence of Malignancy vs absence of malignancy (ref.) | 0.98 | 0.88 – 1.09 |
| Presence of AIDS/HIV vs absence of AIDS/HIV (ref.) | 0.85 | 0.51 – 1.42 |
| Presence of depression vs absence of depression (ref.) | 1.70 | 1.57 – 1.85 |
| Body mass index (+1 kg/m2) | 0.98 | 0.98 – 0.99 |
| Presence of OSA vs absence of OSA (ref.) | 4.28 | 3.98 – 4.61 |
| Presence of PLMS vs absence of PLMS (ref.) | 4.83 | 3.94 – 5.92 |
Cardiovascular Disease was defined as acute myocardial infraction, angina, coronary artery disease, previous coronary artery bypass grafting or percutaneous coronary intervention
Abbreviations: AIDS: Acquired immundeficiency syndrome; eGFR: Estimated glomerular filtration rate; HIV: Human Immundeficiency Virus; OSA: Obstructive Sleep Apnea; PLMS: Periodic Limb Movements in Sleep; RLS: Restless Legs Syndrome