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. 2016 Mar 18;7:104. doi: 10.3389/fphys.2016.00104

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Copyright © 2016 Gu, Hu, Song, Chen, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rapamycin inhibited cardiac hypertrophy in vivo. (A,B) Whole hearts (A) and H&E staining (B) of normal and aortic banding (AB) mice at 8 weeks post-surgery in the presence or absence of rapamycin and/or PD98059. (C,D) Western blot analysis of the hypertrophy and autophagy markers ANP, BNP, Beclin-1 and Noxa. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. Control. Experiments were repeated three times, n = 3. (E,F) The mRNA expression levels of ANP (F) and BNP (E) in myocardial tissues in each group were measued by Rt-PCR. ^*p < 0.05, ^**p < 0.01 vs. Control. (G,H) Measurements of myocardial cross-sectional area and heart weight/body weight ratio in the response to the indicated treatments. n = 8. ^*p < 0.05, ^**p < 0.01 vs. Control.