Table 2.
miRNAs incorporated into exosomes that targeted endothelial cells modulating angiogenesis.
| miRNA | miRNA source | Recipient cell | Target gene | References |
|---|---|---|---|---|
| miR-21 | Human lung cancer | HBEC | VEGF | Liu et al., 2016 |
| miR-17, miR-20a, miR023a, miR-23b, miR-30b, miR-30c, miR-126-3p, miR-132 | Mice cardiomyocytes | HUVEC | Multiple target gene | Garcia et al., 2015 |
| miR-23, miR-320b | MCF7 | EA.hy926 | PLAU, AMOTL1, NRP1, ETS2 | Hannafon et al., 2015 |
| miR-126 | HUVEC | HUVEC | SPRED1, VECAM1, RGS16, CXCL12 | Zernecke et al., 2009 |
| miR-132 | CPC | HUVEC | RasGAp-p120 | Barile et al., 2014 |
| miR-135b | HR-MM | HUVEC | FIH-1 | Umezu et al., 2014 |
| miR-143 | PASMC | PAEC | Deng et al., 2015 | |
| miR-150 | THP-1 | HMEC-1 | c-Myb | Zhang et al., 2010 |
| miR-320 | Cardiomyocytes | CEC | IGF1, HSP20, Ets2 | Wang X. et al., 2014 |
| miR142-3p, miR-223-3p | BMDM | iECL | Multiple miRNAs | Squadrito et al., 2014 |
HBEC, Human bronchial epithelial cells; HUVEC, human umbilical endothelial cells; CPC, cardiac progenitor cells; CEC, cardiac endothelial cells; PASMC, Pulmonary artery smooth muscle cells; PAEC, pulmonary aortic endothelial cells; HR-MM, hypoxia resistant myelomas cell lines (RPMI8226); BMDM, Bone marrow derived macrophages; iECL, immortalized endothelial-like cells from the hearth of Dicerfl∕fl mice.