Figure 2.

Spy7 prevents dissemination of M1 S. pyogenes from an intramuscular focus of infection. Three groups of twelve age-matched female FVB/N mice were vaccinated with Spy7 (open triangles) or CEP-5 (open circles), or sham vaccination with PBS and adjuvant alone (closed squares) and challenged with ∼1 × 10⁷ CFU/mouse of M1 S. pyogenes (strain H305). Solid lines indicate the median CFU recovered from each organ 24 h post infection. *p < 0.05 Kruskal–Wallis (Dunns post-test) ND: Not Detected.