Figure 3.

Spy7 prevents dissemination of M3 S. pyogenes from an intramuscular focus of infection. Two groups of twelve age-matched female FVB/N mice were vaccinated with Spy7 (open triangles) or sham vaccination with PBS and adjuvant alone (closed squares) and challenged with ∼1 × 10⁷ CFU/mouse of M3 S. pyogenes (strain H330). Solid lines indicate the median CFU recovered from each organ 24 h post infection. *p < 0.05 two-tailed Mann–Whitney U. ND: Not Detected.