Table 2.
Parameters of renal O 2 exchange, metabolism, function (NGAL - neutrophil gelatinase-associated lipocalin), as well as renal venous biomarkers of inflammation (NO 2 - + NO 3 - - nitrite plus nitrate) and oxidative stress (n.d. - not determined)
| Before peritonitis | 12-h peritonitis | 24-h peritonitis | ||
|---|---|---|---|---|
| Renal venous PO2 (mmHg) | DMSO | 54 (45, 61) | 60 (50, 61) | 56 (47, 61) |
| GW0742 | 53 (47, 55) | 58 (52, 63) | 56 (48, 60) | |
| Renal venous PCO2 (mmHg) | DMSO | 40 (38, 41) | 44 (41, 45) | 45 (41, 47) |
| GW0742 | 38 (36, 40) | 44 (42, 45) | 42 (37, 46) | |
| Renal venous pH | DMSO | 7.42 (7.41, 7.44) | 7.42 (7.36, 7.44) | 7.30 (7.12, 7.39)a |
| GW0742 | 7.43 (7.40, 7.45) | 7.42 (7.38, 7.44) | 7.31 (7.23, 7.40)a | |
| Renal venous base excess (mmol1·L-1) | DMSO | 1.4 (0.0, 2.5) | 2.4 (-0.2, 4.7) | -4.4 (-12.3, 1.5)a |
| GW0742 | 1.0 (0.1, 1.7) | 3.3 (1.3, 4.4) | -4.7 (-8.2, -2.1)a | |
| Renal venous lactate (mmol1·L-1) | DMSO | 0.9 (0.7, 1.4) | 1.0 (0.9, 1.9) | 4.1 (1.3, 9.2)a |
| GW0742 | 1.0 (0.7, 1.0) | 1.3 (1.2, 1.5) | 3.2 (2.1, 4.3)a | |
| Arterial creatinine (μmol1·L-1) | DMSO | 90 (84, 96) | 81 (75, 96) | 126 (98, 141)a |
| GW0742 | 93 (87, 95) | 81 (80, 88) | 124 (94, 137)a | |
| Blood NGAL (ng·L-1) | DMSO | 65 (55, 72) | n.d. | 364 (270, 400)a |
| GW0742 | 56 (53, 61) | n.d. | 365 (276, 400)a | |
| Urine output (mL·kg-1·h-1) | DMSO | 8.8 | (7.7, 10.4) | 3.2 (1.8, 5.1)a |
| GW0742 | 10.0 | (8.2, 10.7) | 3.6 (2.4, 6.7)a | |
| Creatinine clearance (mL1·min-1) | DMSO | 120 | (91, 134) | 56 (39, 96)a |
| GW0742 | 129 | (114, 140) | 78 (66, 81)a | |
| Fractional Na+ excretion (%) | DMSO | 10 | (8, 11) | 5 (4, 8)a |
| GW0742 | 8 | (7, 9) | 4 (3, 4)a | |
| Renal venous interleukin-6 (ng·L-1) | DMSO | 96 (77, 139) | 1,710 (1,242, 4,807)a | 8,405 (2,565, 23,153)a |
| GW0742 | 97 (77, 107) | 2,656 (1,186, 2,910)a | 3,457 (3,348, 3,489)a | |
| Renal venous tumor necrosis factor-α (ng·L-1) | DMSO | 34 (28, 52) | 70 (55, 105)a | 125 (91, 172)a |
| GW0742 | 49 (42, 126) | 63 (50, 84)a | 183 (131, 239)a | |
| Renal venous NO2 - + NO3 - (μmol·L-1) | DMSO | 7 (5, 14) | 10 (8, 15) | 14 (12, 21)a |
| GW0742 | 9 (6, 10) | 9 (8, 14) | 17 (10, 21)a | |
| Renal venous 8-isoprostane (ng·L-1) | DMSO | 85 (80, 131) | 96 (78, 132) | 123 (90, 166)a |
| GW0742 | 83 (72, 109) | 91 (70, 113) | 123 (87, 264)a |
Data on urine output, creatinine clearance, and fractional Na+ excretion refer to 0 to 12 and 12 to 24 h of peritonitis, respectively. All data are presented as median (quartiles); vehicle (DMSO): n = 12 (n = 11 at 24-h peritonitis), GW0742: n = 10; a p < 0.05 vs. before peritonitis.