Fig. 1.

Hypobaric hypoxia (HH) exposure increases right ventricular (RV) myocyte size in both wild-type (WT) and interleukin (IL)-18 knockout (KO) mice compared with control (CO), with a moderate increase in cell size in WT mice compared with KO. RV sections were stained with hematoxylin and eosin (H&E), and cell size was measured in the circumferential plane. Two animals from each cohort were assessed, and cell size was repeatedly measured within each cohort. CO WT (n = 25), HH WT (n = 16), CO KO (n = 25), HH KO (n = 17). Open bars, CO; filled bars, HH.