Fig. 6.

Compensatory upregulation of other proinflammatory cytokines IL-2 and stromal cell-derived factor-1 (SDF-1) in HH KO mice. A commercially available cytokine profile array was used to assess the expression of 40 chemokines and cytokines in all 4 groups. Log ratios of HH/CO were calculated within each genotype, and those with a fold change of >2 are reported in A. Only 14 proteins were induced >2-fold within each genotype, and, of these, only 7 showed differential expression between KO and WT mice (B). Green indicates significantly induced in the HH compared with CO, and proteins in red were significantly repressed in the HH compared with CO; n = 4 mice/group, with biological duplicates. BLC, B lymphocyte chemoattractant; C5a, complement component 5a; G-CSF, granulocyte-colony stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor, IFN-γ, interferon-γ; IL, interleukin; KC, keratinocyote chemoattractant; M-CSF, macrophage colony-stimulating factor; TARC, thymus and activation-regulated chemokine; TNF-α, tumor necrosis factor-α.