Table 1.
Seven weeks of exposure to HH causes mild pulmonary hypertension and RV remodeling in both WT and IL-18 KO mice
| Body Wt, g | RV Wt, g | Lung Wt, g | RV/LV | HR, beats/min | RVSP, mmHg | PAAT, ms | RVAW, mm | |
|---|---|---|---|---|---|---|---|---|
| WT CO | 24.1 ± 1.6 | 0.025 ± 0.004 | 0.144 ± 0.009 | 0.275 ± 0.03 | 518 ± 18 | 29.2 ± 3.3 | 16.6 ± 0.31 | 0.37 ± 0.03 |
| WT HH | 23.9 ± 0.7 | 0.041 ± 0.004 | 0.175 ± 0.005 | 0.555 ± 0.06 | 476 ± 17 | 42.4 ± 2.5 | 13.1 ± 0.38 | 0.62 ± 0.05 |
| KO CO | 22.4 ± 0.8 | 0.027 ± 0.003 | 0.137 ± 0.001 | 0.313 ± 0.03 | 476 ± 27 | 28.7 ± 2.8 | 16.8 ± 0.35 | 0.4 ± 0.02 |
| KO HH | 22.8 ± 0.9 | 0.042 ± 0.002 | 0.172 ± 0.002 | 0.585 ± 0.04 | 416 ± 11 | 48.8 ± 0.5 | 14.2 ± 0.64 | 0.61 ± 0.02 |
| CO-HH | NS | <0.001* | <0.001* | <0.001* | <0.05* | <0.001* | <0.001* | <0.001* |
| KO-WT | NS | NS | NS | NS | <0.05* | NS | NS | NS |
| Interaction | NS | NS | NS | NS | NS | NS | NS | NS |
Values are means ± SE. Exposure to hypobaric hypoxia (HH) (7 wk) causes mild pulmonary hypertension and right ventricular (RV) remodeling in both wild-type (WT) and interleukin (IL)-18 knockout (KO) mice compared with control (CO). BW, body weight; RV/LV, right-to-left ventricle ratio; HR, heart rate; RSVP, right ventricular systolic pressure; PAAT, pulmonary artery acceleration time; RVAW, right ventricular anterior wall thickness.
*
Statistically significant difference; NS, not significant.