Fig. 2.

Metabolic phenotype at 12 wk. A. Mean ± SE circadian analysis of total energy expenditure (Tot_EE) (left) and total activity (right) for day and night phases over a 48-hperiod in mice fed LFWD, HFWD, LFWD+F/S, or HFWD+F/S. B: circadian analysis of food intake in chow, HFWD, and HFWD+F/S groups. A and B: different letters indicate significantly different values at P < 0.05. C: means ± SE of Avg_EE, Avg_RQ, and Ped_meters every 8 min during the 24-h period for LFWD vs. LFWD+F/S (left) and HFWD vs. HFWD+F/S (right) groups. Black stars, significant increases (P < 0.05) in LFWD and HFWD groups over LFWD+F/S and HFWD+FS groups (left and right, respectively); gray stars, significant increases (P < 0.05) in LFWD+F/S and HFWD+FS groups over LFWD and HFWD groups (left and right, respectively).