Fig. 1.
Systolic blood pressure (SBP) in DOCA-salt hypertensive rats. SBP was measured by tail-cuff plethysmography in uninephrectomized rats (UNx; circles), DOCA-salt rats (diamonds), DOCA-salt rats treated with pentosan polysulfate (PPS; DOCA-salt+PPS; 100 mg·kg−1·day−1, squares), and DOCA-salt rats treated with triple therapy (DOCA-salt+TTx; hydralazine, hydrochlorothiazide, and reserpine, triangles) from the metabolic studies. PPS did not alter the progression or magnitude of hypertension in DOCA-salt rats through the 21-day treatment period. TTx treatment suppressed the development of hypertension in DOCA-salt rats. Values are means ± SE. *P < 0.05 vs. SBP on day 0. †P < 0.05 vs. UNx.