Table 1.
Comparison of metabolic parameters
| Day 0 |
Day 7 |
Day 14 |
Day 21 |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UNx | DOCA | DOCA+PPS | DOCA+TTx | UNx | DOCA | DOCA+PPS | DOCA+TTx | UNx | DOCA | DOCA+PPS | DOCA+TTx | UNx | DOCA | DOCA+PPS | DOCA+TTx | |
| Body weight, g | 278 ± 4 | 288 ± 9 | 299 ± 6 | 291 ± 5 | 308 ± 4* | 294 ± 12 | 311 ± 9& | 240 ± 11*†# | 336 ± 6* | 315 ± 15* | 322 ± 9*& | 256 ± 12†# | 358 ± 9* | 321 ± 21 | 328 ± 11* | 302 ± 21 |
| Food intake, g | 27 ± 2 | 26 ± 2 | 25 ± 1 | 26 ± 1 | 21 ± 1 | 17 ± 3* | 23 ± 2& | 13 ± 3*# | 23 ± 2 | 22 ± 3 | 22 ± 3 | 21 ± 4 | 21 ± 3 | 25 ± 2 | 21 ± 2 | 31 ± 7 |
| Water intake, ml/day | 39 ± 2 | 43 ± 4 | 37 ± 2 | 40 ± 3 | 35 ± 2 | 138 ± 15*†& | 147 ± 13*†& | 23 ± 6 | 33 ± 3 | 178 ± 13*†& | 160 ± 21*†& | 61 ± 12 | 35 ± 4 | 161 ± 15*†& | 149 ± 21*†& | 38 ± 7# |
| Urine volume, ml/day | 14 ± 1 | 17 ± 3 | 13 ± 1 | 13 ± 1 | 17 ± 1 | 101 ± 15*†& | 113 ± 11*†& | 22 ± 7# | 18 ± 2 | 149 ± 12*†& | 130 ± 18*†& | 46 ± 8*†# | 19 ± 2 | 134 ± 15*†& | 122 ± 18*†& | 36 ± 8†# |
Values are means ± SE; n = 12, 9, 12, and 7 for uninephrectomized (UNx), DOCA plus 1% NaCl in the drinking water (DOCA-salt), DOCA-salt+pentosan polysulfate (PPS), and DOCA-salt+“triple therapy” (hydrochlorothiazide, hydralazine, and reserpine (TTx) rats, respectively. DOCA indicates DOCA-salt.
*
P < 0.05 vs. day 0 in the same group.
†
P < 0.05 vs. UNx group during the same collection period.
#
P < 0.05 vs. DOCA-salt+PPS group during the same collection period.
&
P < 0.05 vs. DOCA-salt+TTx group during the same collection period.