Fig. 1.

Survival curve of animals treated with the standard dosing model and repeated dosing model. Eight-week-old male FVB mice were injected (intraperitoneally) with saline vehicle or cisplatin (7 or 9 mg/kg) once a week for 4 wk (repeated dosing model) or with 25 mg/kg cisplatin given once (standard dosing model). Mice were monitored daily for weight loss and changes in overall well-being and were euthanized when moribund in accordance to Institutional Animal Care and Use Committee guidelines. At day 24, surviving mice were euthanized and analyzed.