Fig. 7.
γ-Secretase inhibitor reduces the response of TβRIIflox/flox, but not TβRII−/−, PT cells to HGF. A: representative images of PT cells pretreated with γ-secretase or DMSO and stimulated with HGF (see methods), plated on Matrigel-coated chamber slides, and stained with rhodamine-phalloidin. Magnification ×400; scale bar = 50 μm. B: representative images showing migration on Matrigel-coated Transwell inserts repeated with all cells stimulated by HGF + γ-secretase or DMSO. Magnification ×200, scale bars = 50 μm. C: migrated cells were counted in a blinded manner in 10 fields per sample (n = 3). Values are means ± SE. *P < 0.05.