Fig. 4.

Adoptive transfer colitis is less severe in mice lacking epithelial myosin light chain kinase (MLCK). A: Rag1^−/−MLCK^−/− and Rag1^−/− received naïve T cells. MLCK knockout (KO) mice were protected from weight loss at early, but not late, stages of disease. B: intestinal permeability is increased in Rag1^−/−, but not Rag1^−/−MLCK^−/−, at day 15 after adoptive transfer. This difference is abrogated by day 35 and coincides with increased epithelial apoptosis. C: despite weight loss, epithelial MLCK knockout mice demonstrate protection from histopathological evidence of disease at early and late times. [From Su et al. (83) with permission from Elsevier.]