Table 1.
Association of polymorphisms within the toll-like receptor 4 gene region with clinical subtypes of psoriasis
| SNP | Chr 9bp position | A1/A2 | Function | Imputed controls (n = 4861) | Patients with psoriasis (n = 2826) | |||
|---|---|---|---|---|---|---|---|---|
| MAF | Imp.Info. score | MAF | Allelic p (SE) | OR (95 % CI) | ||||
| rs10818070 | 119496316 | A/G | Intergenic | 0.07 | 1.000 | 0.08 | 0.0419 (0.06) | 1.13 (1.01–1.28) |
| rs10759930 | 119501442 | T/C | Upstream | 0.38 | 1.000 | 0.36 | 0.0360 (0.03) | 0.93 (0.87–1.00) |
| rs2737191 | 119502536 | G/A | Upstream | 0.29 | 1.000 | 0.29 | 0.6362 (0.04) | 1.02 (0.95–1.09) |
| rs10116253 | 119504141 | C/T | Upstream | 0.25 | 0.999 | 0.26 | 0.7027 (0.04) | 1.02 (0.94–1.09) |
| rs10759932 | 119504965 | C/T | Upstream | 0.13 | 0.999 | 0.14 | 0.1231 (0.05) | 1.08 (0.98–1.19) |
| rs12344353 | 119508470 | C/T | Intronic | 0.06 | 0.998 | 0.07 | 0.0005 (0.07) | 1.27 (1.11–1.45) |
| rs11536871 | 119510319 | C/A | 5′ UTR/Intronic | 0.04 | 1.000 | 0.04 | 0.1132 (0.08) | 1.14 (0.97–1.34) |
| rs11536878 | 119511374 | A/C | Intronic | 0.12 | 1.000 | 0.12 | 0.3100 (0.05) | 0.95 (0.86–1.05) |
| rs1927907 | 119512585 | T/C | Intronic | 0.13 | 0.997 | 0.14 | 0.1468 (0.05) | 1.07 (0.98–1.18) |
| rs2149356 | 119514020 | T/G | Intronic | 0.31 | 0.997 | 0.33 | 0.0118 (0.04) | 1.10 (1.02–1.17) |
| rs4986790 | 119515123 | G/A | Missense | 0.05 | 1.000 | 0.07 | 0.0002 (0.07) | 1.30 (1.13–1.48) |
| rs7873784 | 119518757 | C/G | 3′ UTR | 0.16 | 0.998 | 0.15 | 0.5298 (0.05) | 0.97 (0.89–1.06) |
| rs1927906 | 119519936 | C/T | Downstream | 0.09 | 1.000 | 0.11 | 0.0053 (0.06) | 1.17 (1.05–1.30) |
| rs1554973 | 119520633 | C/T | Downstream | 0.25 | 1.000 | 0.26 | 0.1249 (0.04) | 1.06 (0.98–1.14) |
| rs7044464 | 119521218 | A/T | Downstream | 0.16 | 0.999 | 0.15 | 0.6902 (0.05) | 0.98 (0.90–1.08) |
| rs7037225 | 119523460 | T/C | Downstream | 0.15 | 1.000 | 0.16 | 0.0958 (0.05) | 1.08 (0.99–1.18) |
| rs913930 | 119523830 | G/A | Downstream | 0.37 | 1.000 | 0.37 | 0.7308 (0.03) | 1.01 (0.95–1.08) |
| rs2183016 | 119525036 | C/A | Intergenic | 0.16 | 1.000 | 0.15 | 0.5178 (0.05) | 0.97 (0.89–1.06) |
| rs1927905 | 119525129 | C/T | Intergenic | 0.06 | 1.000 | 0.05 | 0.2272 (0.07) | 0.91 (0.79–1.06) |
| rs10759934 | 119528817 | T/A | Downstream | 0.48 | 0.972 | 0.47 | 0.0622 (0.03) | 0.94 (0.88–1.00) |
| SNP | PSA confirmed patients (n = 1839) | Early-onset psoriasis (n = 1466) | Late-onset psoriasis (n = 671) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MAF | Allelic p (SE) | OR (95 % CI) | MAF | Allelic p (SE) | OR (95 % CI) | MAF | Allelic p (SE) | OR (95 % CI) | |
| rs10818070 | 0.09 | 0.0272 (0.07) | 1.17 (1.02–1.34) | 0.09 | 0.0269 (0.08) | 1.18 (1.02–1.37) | 0.08 | 0.5374 (0.11) | 1.07 (0.87–1.32) |
| rs10759930 | 0.36 | 0.0148 (0.04) | 0.91 (0.84–0.98) | 0.37 | 0.3513 (0.04) | 0.96 (0.88–1.05) | 0.36 | 0.2098 (0.06) | 0.93 (0.82–1.04) |
| rs2737191 | 0.29 | 0.7939 (0.04) | 1.01 (0.93–1.10) | 0.29 | 0.9495 (0.05) | 1.00 (0.91–1.09) | 0.30 | 0.5233 (0.06) | 1.04 (0.92–1.18) |
| rs10116253 | 0.26 | 0.2268 (0.04) | 1.06 (0.97–1.15) | 0.25 | 0.6751 (0.05) | 0.98 (0.89–1.08) | 0.25 | 0.9297 (0.07) | 0.99 (0.87–1.13) |
| rs10759932 | 0.14 | 0.0548 (0.06) | 1.11 (1.00–1.24) | 0.13 | 0.4063 (0.06) | 1.05 (0.93–1.19) | 0.14 | 0.3620 (0.08) | 1.08 (0.91–1.28) |
| rs12344353 | 0.07 | 0.0007 (0.08) | 1.30 (1.12–1.51) | 0.07 | 0.0009 (0.08) | 1.32 (1.12–1.56) | 0.07 | 0.0754 (0.12) | 1.23 (0.98–1.55) |
| rs11536871 | 0.04 | 0.1840 (0.10) | 1.14 (0.94–1.37) | 0.05 | 0.0755 (0.10) | 1.20 (0.98–1.47) | 0.04 | 0.9280 (0.15) | 1.01 (0.76–1.36) |
| rs11536878 | 0.12 | 0.8061 (0.06) | 0.99 (0.88–1.11) | 0.11 | 0.1440 (0.07) | 0.91 (0.80–1.03) | 0.12 | 0.4645 (0.09) | 0.94 (0.78–1.12) |
| rs1927907 | 0.14 | 0.0765 (0.06) | 1.11 (0.99–1.23) | 0.14 | 0.4211 (0.06) | 1.05 (0.93–1.19) | 0.14 | 0.4621 (0.09) | 1.07 (0.90–1.26) |
| rs2149356 | 0.34 | 0.0042 (0.04) | 1.13 (1.04–1.22) | 0.33 | 0.1048 (0.05) | 1.08 (0.98–1.18) | 0.33 | 0.1741 (0.06) | 1.09 (0.96–1.23) |
| rs4986790 | 0.07 | 0.0002 (0.08) | 1.33 (1.14–1.55) | 0.07 | 0.0008 (0.08) | 1.33 (1.13–1.57) | 0.07 | 0.0181 (0.12) | 1.31 (1.05–1.65) |
| rs7873784 | 0.16 | 0.7570 (0.05) | 1.02 (0.92–1.13) | 0.14 | 0.0531 (0.06) | 0.89 (0.79–1.00) | 0.16 | 0.4379 (0.08) | 1.06 (0.91–1.24) |
| rs1927906 | 0.11 | 0.0047 (0.06) | 1.20 (1.06–1.36) | 0.11 | 0.0156 (0.07) | 1.18 (1.03–1.36) | 0.11 | 0.0630 (0.09) | 1.19 (0.99–1.44) |
| rs1554973 | 0.27 | 0.0251 (0.04) | 1.10 (1.01–1.20) | 0.25 | 0.7596 (0.05) | 1.02 (0.92–1.12) | 0.27 | 0.0660 (0.07) | 1.13 (0.99–1.28) |
| rs7044464 | 0.16 | 0.7371 (0.05) | 1.02 (0.92–1.13) | 0.14 | 0.1082 (0.06) | 0.91 (0.81–1.02) | 0.16 | 0.4379 (0.08) | 1.06 (0.91–1.24) |
| rs7037225 | 0.17 | 0.0814 (0.05) | 1.10 (0.99–1.22) | 0.16 | 0.2350 (0.06) | 1.07 (0.96–1.20) | 0.17 | 0.2129 (0.08) | 1.10 (0.95–1.29) |
| rs913930 | 0.37 | 0.9862 (0.04) | 1.00 (0.92–1.08) | 0.37 | 0.8602 (0.04) | 1.01 (0.92–1.10) | 0.36 | 0.8490 (0.06) | 0.99 (0.88–1.11) |
| rs2183016 | 0.16 | 0.7878 (0.05) | 1.01 (0.91–1.13) | 0.14 | 0.0577 (0.06) | 0.89 (0.79–1.00) | 0.16 | 0.4963 (0.08) | 1.06 (0.90–1.23) |
| rs1927905 | 0.05 | 0.2980 (0.09) | 0.91 (0.77–1.08) | 0.05 | 0.1637 (0.10) | 0.87 (0.72–1.06) | 0.05 | 0.8037 (0.13) | 0.97 (0.75–1.25) |
| rs10759934 | 0.47 | 0.2435 (0.04) | 0.96 (0.88–1.03) | 0.47 | 0.1281 (0.04) | 0.94 (0.86–1.02) | 0.48 | 0.6212 (0.06) | 0.97 (0.87–1.09) |
PS psoriasis patients, PSA psoriatic arthritis, Chr 9 chromosome 9, Bp base pairs, SE standard error, Imp.Info. Score imputation information score, MAF minor allele frequency, 95 % CI 95 % confidence interval, OR odds ratio