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. 2016 Mar 15;7:10997. doi: 10.1038/ncomms10997

Figure 2. Arp2/3-based actin polymerization is required for DC passage through constrictions.

Figure 2

(a) Percentage of passage and (b) passage time in 2-μm-wide constrictions. Blebbi, blebbistatin; LatA, latrunculin A; MT, microtubules; Noco, nocodazole. (c) Mean instantaneous speed in straight 7-μm-wide channels. (d) Non-passage time in 2-μm-wide constrictions. (e) Left: schematic of the nuclear entry events. Right: percentage of nuclear entry in non-passing cells. (a,b,d,e) Numbers in bars represent the number of scored cells. (c) Numbers in bars represent the number of cell tracks for each condition. ***P-value<0.0001, **P-value<0.001 and *P-value<0.01; NS, nonsignificant. Statistical test: Fisher's test for a and e, Mann–Whitney test for b,c and d. Error bars are s.e.m. N≥3.