Table 3.

Cost parameters

Cost description	Base case estimate (USD)	Reference
AC-T treatment overall cost	3294	(Haghighat, 2013)
Trastuzumab drug cost	48850	(ICRN, 2011)
Trastzumab administration cost	425	Local charge
Annual disease free Follow-up costs (mammography, medical visits, for 3 years)	47	Calculated based on Guideline (NICE, 2002)
Loco-regional overall cost	4138	(Haghighat, 2013)
Metastases diseases annual cost	7865	(Davari et al., 2013)
Congestive heart failure cost	675	Calculated based on Guideline (NICE, 2010)

AC-T: doxorubicin and cyclophosphamide followed by docetaxel.

AC-TH: doxorubicin and cyclophosphamide followed by docetaxel plus trastuzumab.