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. 2016 Mar 17;6:26. doi: 10.1186/s13550-016-0180-0

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© Burvenich et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Nano-SPECT/MRI imaging with ¹⁷⁷Lu-CHX-A″ DTPA-labelled hu3S193 wild type (a, d) and I253A/H310A mutant (b, e) and huA33 wild type antibody (c, f) at day 2 post injection in A431 tumour-bearing mice. Representative whole body surface-rendered MRI images (a–c) and maximum intensity projection SPECT image (d–f) are shown for each antibody. The T1 weighted MRI images clearly show the tumour (grey solid mass) surface of the lower abdomen, corresponding to the specific uptake of ¹⁷⁷Lu-CHX-A″ DTPA-labelled hu3S193 wild type and I253A/H310A in tumours expressing Le^y. Specific uptake of both hu3S193 wild type and hu3S193 I253A/H310A was demonstrated by the absence of huA33 uptake in the A33 antigen-negative A431 tumours