Table 2.

Catalytic activity and selectivity of myoglobin variants in benzaldehyde olefination with EDA.^[a]

Entry	Catalyst	Y	TON	de (E)	TON(3a)/TON(4a)
1	WT Mb	PPh3	31	76%	2.8
		AsPh3	27	99.9%	0.7
2	Mb(L29A)	PPh3	16	79%	0.8
		AsPh3	34	99.9%	0.5
3	Mb(F43V)	PPh3	20	69%	1.2
		AsPh3	35	99.9%	1.1
4	Mb(F43W)	PPh3	30	68%	6.0
		AsPh3	56	99.9%	2.7
5	Mb(H64V)	PPh3	37	69%	1.7
		AsPh3	35	99.9%	0.5
6	Mb(V68A)	PPh3	13	69%	0.5
		AsPh3	36	99.9%	1.1
7	Mb(V68F)[b]	PPh3	28	64	0.7
		AsPh3	82	94	1.9
8	Mb(L29A,H64V)	PPh3	57	70%	1.4
		AsPh3	50	80%	0.5
9	Mb(H64V,V68A)	PPh3	7	73%	0.8
		AsPh3	16	57%	0.2
10	Mb(F43V,V68F)	PPh3	38	64%	2.9
		AsPh3	92	99.9%	3.3
11	Mb(F43V,V68F)[c]	AsPh3	1,170	99.9%	4.2

^[a]Reaction conditions are the same as in Table 1.

^[b]With 5 μM catalyst (0.05 mol%).

^[c]With 1 μM catalyst (0.01 mol%).