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The coiled-coil helix coiled-coil helix protein (CHCHD10) is encoded by four exons. Both mutations occur in exon 2 (a). Predicted structural and functional domains of CHCHD10, a protein of 142 amino acids, are shown (b). The only predicted structural and functional domain is a CHCH domain (102-133). Sequence analysis revealed an N-terminal mitochondrial localization signal (M; amino acids 1-16).
